More recently, bitter gourd juice was shown to kill pancreatic cancer cells in vitro and in mice in a study done by the University of Colorado. Considering the results were seen in both in vitro and in vivo tests, the effectiveness of bitter gourd juice in treating pancreatic cancer, and potentially other cancers, at a clinical level are promising.
Studies showed that bitter gourd juice also inhibits proliferation, induces apoptosis and activates AMPK (adenosine monophosphate-activated protein kinase) in vivo. Overall, bitter gourd juice exerts strong anticancer efficacy against human pancreatic carcinoma cells, both in vitro and in vivo, suggesting its clinical usefulness.
Pancreatic cancer is one of the most difficult cancers to treat due to the fact that it is often discovered late, leaving very little time to treat. Since traditional therapies (chemotherapy, radiation, surgery etc) were not showing promising results and littler advancement was being made, researchers have been looking elsewhere to find treatment.
Many cancerous tumors have insulin receptors which move glucose to cancer cells helping them to grow and divide. Studies have shown that insulin encourages pancreatic cancer cells to grow in a dose-dependent manner, since bitter gourd has been shown to help regulate insulin levels, this could help prevent pancreatic cancer over the long-term.
The Colorado University study was led by Dr. Rajesh Agarwal. They examined effects of bitter gourd on 4 different lines of pancreatic cancer cells (in vitro) and in mice. For the in vivo studies, mice were injected with pancreatic tumor cells and were randomly divided into one of two groups. One group of mice received water, which was the control group, and the other group was given bitter gourd juice for six weeks.
Researchers studied the tumors at the end of the study and results showed that bitter gourd juice not only inhibited cancer cell proliferation but also induced apoptosis (programmed cell death). Compared to the control, tumor growth was inhibited by 60% in the treatment group and there were no signs of toxicity or negative effects on the body. With toxicity and negative effects being a huge role in traditional mainstream treatments, this was positive to see.
A number of clinical studies have been conducted to evaluate the efficacy of bitter gourd for treating diabetes. Since it is believed that diabetes is a precursor for pancreatic cancer, researchers felt bitter gourd could treat diabetes as well after seeing pancreatic cancer results.
In 2011, results of a four-week long clinical trial were published in the Journal of Ethnopharmacology that showed modest hypoglycemic effects and significant fructosamine management for those taking 2000mg/day of bitter gourd.
As published by the study: “Bitter gourd had a modest hypoglycemic effect and significantly reduced fructosamine levels from baseline among patients with type 2 diabetes who received 2,000 mg/day. However, the hypoglycemic effect of bitter gourd was less than metformin 1,000 mg/day.”
Another study published in 2008 in the international journal Chemistry and Biology indicated that compounds in bitter gourd improved glycemic control, helped cells uptake glucose and improved overall glucose tolerance. This study was done in mice and led to promising advancements in treating diabetes and obesity with bitter gourd.
In contrast, a study published in the Journal of Clinical Epidemiology in 2007 did not show significant benefit of the treatment of diabetes by bitter gourd but 2 years later in the British Journal of Nutrition it was stated that “more, better-designed and clinical trials are required to confirm the vegetable’s role in diabetes treatment.”
Since that 2007 study, more studies have been done to show beneficial effects which perhaps was a result of better design.
So, what are you waiting for? Start growing bitter gourd in your own vegetable garden asap and should you need any help in organic home gardening, get in touch with Vandana at 9535025938 or send in a mail at [email protected]